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A marked downregulation of Оґ and Оі2 subunits accompanied by significant decrease in tonic and phasic inhibitions are observed in pregnant mice, which rebounds immediately postpartum Maguire and Mody, 2008 buy nolvadex However, a phase I trial testing the combination of buparlisib and olaparib reported modest results in terms of efficacy with relevant additional toxicity 117
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